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KMID : 0370219950390060671
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Yakhak Hoeji
1995 Volume.39 No. 6 p.671 ~ p.675
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The Influence of Methanol Extract of Ulmus davidiana var. japonica Cortex on Gastric Erosion and Ulcer and Paw Edema in Rats
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이은방/Lee EB
김옥경/정춘식/정기화/Kim OK/Jung CS/Jung KW
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Abstract
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The bark of Ulmus davidiana var. japonica(Ulmaceae) has been described in traditional books to have diuretic and laxative actions, to ameliorate edematous disease, and to be used in insomnia and gastrointestinal disorders. Thus this study was carried out to elucidate some of the pharmacological activities of the plant extracts. The results obtained in this experiment indicated that its methanol extract elicited remarkable inhibition of HCl-ethanol induced gastric lesion, Shay ulceration and gastric secretion. However, it showed no anti-inflammatory action. The acute toxicity of the extract was low, that is, the minimum lethal dose was more than 2000mg/kg by oral administration in mice. The systematic fractionation of the methanol extract by hexane, ether, ethylacetate and butanol resulted in potent prevention of gastric erosion in butanol and water fractions.
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